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Years have passed after the appearance on the market of Viagra, Cialis and Levitra, but scientists-pharmacists have developed nothing new to treat erectile dysfunction. Those to whom these preparations did not suit have felt disappointed. But quite recently the pharmaceutical market has flown around the news of a new, and fundamentally new, drug – Stendra. After some time many generics of this drug appear on the market which is sold in online pharmacies including Canadian Pharmacy.
What is generic Stendra?
Generic Stendra (Avanafil) is a preparation for oral administration. It is produced to treat erectile dysfunction (impotence) of varying severity. Modern men very often come across with sexual problems. The most common of these disorders is erectile dysfunction. ED means a physiological condition, in which a man is completely unable to achieve or maintain an erection. There are many reasons for impotence. Most often, they are a polluted environment, a high stress load, psychological overloading, abuse of nicotine and alcohol. This is the youngest drug for erection improvement. In its development, the most advanced pharmacological methods were used.
Description and a brief history of creation
At specialized forums, you can often see the question: “What is Stendra 200 mg?” The interest of men in the new drug is understandable. Currently, the main means of treating impotence are:
These drugs belong to the group of PDE-5 inhibitors. They have been in the market for a long time. Therefore, doctors and consumers have studied them well. The new-generation medicine has a more selective effect and almost no side effects.
The new remedy was developed by Vivus. This is a small pharmaceutical company, whose headquarters are located in Mountain View (California, USA). The process of drug development is the basis for the documentary film Orgasm Inc (2009). The US agency FDA approved this medicine April 27, 2012. European Agency EMA approved the drug on June 21, 2013. In Europe, it is sold under the trademark Spedra. It’s the same Stendra. The manufacturer subsequently (July 2013) signed a cooperation agreement with the Menarini Group (a subsidiary of Berlin Chemie). Currently, the drug is sold in more than 40 states.
Mechanism of action
The active component of this drug is Avanafil. This is the first active substance in the world, the effect of which manifests itself within 15 minutes. Like other medications for erectile dysfunction, this drug is included in a large group of type 5 phosphodiesterase inhibitors. It stimulates the blood flow increase to the cavernous bodies to provide a natural erection.
When a man experiences strong sexual excitement, a nitrogen monoxide (NO) begins to be released into the penis, stimulating the production of the guanylate cyclase enzyme. First of all, cGMP is responsible for relaxing the penile smooth muscles and expanding of the blood vessels. After the appearance of cGMP, blood begins to actively enter the cavernous bodies. The latter is similarly tensed and enlarged in size.
How does Stendra work on women?
The excitement of the female genitalia proceeds approximately in the same way as that of the male. Therefore, it is often used male drugs for an erection to increase the female libido. However, at this time, Avanafil was studied only for male application. The influence of Avanafil on the female body has not been studied. Therefore, the drug is intended exclusively for men.
Time of action
Stendra is the first treatment of ED, which begins to function within 15 minutes. It is highly effective in the treatment of erectile dysfunction. During the placebo-controlled clinical trials in all groups, the effectiveness of the drug was 80% or higher. It is perfectly tolerated at any age. Nevertheless, the manufacturer recommends that it should be taken cautiously to men over 60 years of age. The duration of the action can last 4-6 hours. This factor is influenced by such conditions as overweight, fatigue, sickness, etc.